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Benefits of the Ketogenic Diet and Fasting

Paola Spadaro Rodriguez

July 5, 2023
The ketogenic diet began to be studied over 100 years ago in the treatment of epilepsy in pediatric patients, proving to be effective in reducing the frequency of epileptic seizures. Years later, a cardiologist named Dr. Atkins implemented it in patients who wanted to lose weight and improve their cardiovascular health.


In the 1990s, the ketogenic diet gained popularity, but it was also accompanied by some excesses. However, this also led to scientific research being conducted. Thanks to these investigations, we now know that the ketogenic diet can also be beneficial in reducing glucose levels, fatty liver, certain types of cancer, psychiatric disorders, cognitive improvement, body composition, and more.

Scientific research has revealed that combining the ketogenic diet with intermittent fasting can have additional benefits for the body and the brain. In this article, we will explore the latest scientific discoveries regarding this powerful combination and how it can optimize your health.

Ketogenic Diet:

The ketogenic diet is a low-carbohydrate, high-healthy-fat nutritional approach. By drastically reducing carbohydrate intake and increasing the consumption of fats, a metabolic state called ketosis is induced, where the body uses ketones as an energy source instead of glucose. Numerous studies have demonstrated the following benefits of the ketogenic diet:

  • Weight loss: The ketogenic diet can effectively aid in weight loss due to reduced carbohydrate intake and increased satiety.
  • Improved metabolic health: The ketogenic diet has shown to improve insulin sensitivity, regulate blood sugar levels, and reduce inflammation.
  • Enhanced mental clarity: By providing a consistent energy source to the brain, ketones can improve cognitive function and reduce brain fog.

Intermittent Fasting:

Intermittent Fasting involves regular periods of calorie restriction or abstinence from food during certain time intervals. Recent studies have revealed the following benefits of intermittent fasting:

  • Weight Loss: Intermittent fasting can aid in weight loss by reducing overall calorie intake and improving metabolic function.
  • Cellular Protection: During fasting, processes such as autophagy and cellular repair are activated, which can have protective effects against diseases and aging.
  • Improved Insulin Sensitivity: Intermittent fasting has been shown to enhance insulin sensitivity and regulate blood sugar levels.

The Powerful Combination:

The combination of the ketogenic diet with intermittent fasting can enhance the individual benefits of each. Scientific studies have shown that this combination can have the following positive effects:

  • Greater weight loss: The ketogenic diet and intermittent fasting can work synergistically to enhance fat burning and promote greater weight loss.
  • Improved cognitive function: Ketosis and fasting can increase the production of ketones, which are known for their neuroprotective effects and brain function improvement.
  • Reduced inflammation: Both approaches can reduce inflammation in the body, which is associated with numerous chronic diseases.

Scientific References:

  1. Paoli, A., Rubini, A., Volek, J. S., & Grimaldi, K. A. (2013). Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European journal of clinical nutrition, 67(8), 789-796.
  2. Antoni, R., Johnston, K. L., Collins, A. L., & Robertson, M. D. (2018). Intermittent fasting: a potential weight-loss and wellness strategy. New Zealand medical journal, 131(1470), 63-70.
  3. Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., … & Zhang, Z. (2018). Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging. Cell, 173(2), 372-384.
  4. Gasior, M., Rogawski, M. A., & Hartman, A. L. (2006). Neuroprotective and disease-modifying effects of the ketogenic diet. Behavioural pharmacology, 17(5-6), 431-439.
  5. Moller, N., & Jorgensen, J. O. L. (2009). Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocrine reviews, 30(2), 152-177.
  6. Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., … & Cai, H. (2011). AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell metabolism, 13(4), 376-388.

Note: Please note that these references are for informational purposes only and do not constitute medical advice. It is always recommended to consult with a healthcare professional before making any significant dietary changes.


The combination of the ketogenic diet and intermittent fasting offers a powerful tool to improve health and optimize performance. However, it’s important to note that these approaches are not suitable for everyone, and consulting with a healthcare professional and adapting them to your individual needs is essential. Incorporating the ketogenic diet and intermittent fasting properly can provide significant benefits for weight loss, cognitive function, and overall health.

It is important to shift our paradigm and recognize that there are no miracle diets. Beyond weight loss, the goal is to achieve metabolic benefits along with other disciplines that help us maintain a healthy lifestyle.

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